wwPDB validation report of PDB entry 3TIK

Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

sterol 14-alpha demethylase (CYP51) (E.C.1.14.13.70)
Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one

AUTHORS STATE THAT THE BIOLOGICAL ASSEMBLY IN THE MEMBRANE IS A MONOMER. IN THE SOLUTION THE PROTEIN IS CRYSTALLIZED AS A TETRAMER.

The largest off-origin peak in the Patterson function is 4.51% of the height of the origin peak. No significant pseudotranslation is detected.

structure factor analysis and validation
geometric validation package for ligand chemistry in protein x-ray structures
20191225.v01 (using entries in the PDB archive December 25th 2019)