wwPDB validation report of PDB entry 3SQO

Proprotein convertase subtilisin/kexin type 9

Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9

CHAINS A AND P ARE EXPRESSED AS A SINGLE CHAIN. THERE IS AN AUTO-PROTEOLYSIS THAT CUTS THE CHAIN INTO TWO, BUT THE SECOND CHAIN STAYS VERY TIGHTLY ASSOCIATED. IT HAS BEEN THE NOMENCLATURE OF THE PREVIOUSLY PUBLISHED PCSK9 STRUCTURES TO HAVE CHAIN P AS THE PRO-DOMAIN AND CHAIN A AS THE CATALYTIC DOMAIN

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Proprotein convertase subtilisin/kexin type 9 (E.C.3.4.21.-), J16 Heavy chain, J16 Light chain, PCSK9 prodomain (E.C.3.4.21.-)

The largest off-origin peak in the Patterson function is 4.19% of the height of the origin peak. No significant pseudotranslation is detected.

20191225.v01 (using entries in the PDB archive December 25th 2019)
structure factor analysis and validation
geometric validation package for ligand chemistry in protein x-ray structures