wwPDB validation report of PDB entry 5M0L

Phosphorylated at Ser11, Thr198, Ser339; the first 13 amino acids are not well defined in the electron density.
cAMP-dependent protein kinase catalytic subunit alpha

Amino acids 5-24 from cAMP-dependent protein kinase inhibitor alpha from Sigma (order ID: P7739); the last two amino acids are not well defined in the crystal structure
cAMP-dependent protein kinase inhibitor alpha

PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform

5LCQ contains the same protein in complex with a long-chained Fasudil-derivative and is discussed in the same publication

5M0B contains the same protein in complex with a short-chained N-(2-aminoethyl)isoquinoline-5-sulfonamide) Fasudil-derivative (Ligand 03) and is discussed in the same publication

5M0C contains the same protein in complex with the Fasudil-derived fragment isoquinoline-5-sulfonamide (Ligand 01) and is discussed in the same publication

5LCP contains the same protein in complex with the structurally related drug Fasudil (M77)

5LCR contains the same protein in complex with an open-chained Fasudil-derivative

5LCT contains the same protein in complex with a structurally related R-methyl-pierazine substituted Fasudil-derivatives

5LCU contains the same protein in complex with a structurally related S-methyl-pierazine substituted Fasudil-derivative

cAMP-dependent protein kinase catalytic subunit alpha (E.C.2.7.11.11), cAMP-dependent protein kinase inhibitor alpha
Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with the methylated Fasudil-derived fragment N-methylisoquinoline-5-sulfonamide (Ligand 02)

The largest off-origin peak in the Patterson function is 6.15% of the height of the origin peak. No significant pseudotranslation is detected.

20191225.v01 (using entries in the PDB archive December 25th 2019)

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures