wwPDB validation report of PDB entry 6I99

Bone marrow tyrosine kinase gene in chromosome X protein,Epithelial and endothelial tyrosine kinase,ETK,NTK38

NCS used between chain A and chain B
TLS refinement of anisotropic ADPs - 4 non-equivalent rigid bodies were defined per protein chain.
Hydrogen atoms were included in calculated positions.

Cytoplasmic tyrosine-protein kinase BMX (E.C.2.7.10.2)
Bone Marrow Tyrosine Kinase in Chromosome X in complex with a newly designed covalent inhibitor JS24

binding site for Di-peptide H88 B 701 and CYS B 496

The analyses of the Patterson function reveals a significant off-origin peak that is 22.62 % of the origin peak, indicating pseudo-translational symmetry. The chance of finding a peak of this or larger height by random in a structure without pseudo-translational symmetry is equal to 5.4930e-03. The detected translational NCS is most likely also responsible for the elevated intensity ratio. See the relevant section of the logfile for more details.

20191225.v01 (using entries in the PDB archive December 25th 2019)

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures