wwPDB validation report of PDB entry 3H7W

Endothelial PAS domain-containing protein 1
HIF2alpha C-terminal PAS domain (UNP residues 239 to 350)

Aryl hydrocarbon receptor nuclear translocator
ARNT C-terminal PAS domain (UNP residues 356 to 470)

EPAS-1, Member of PAS protein 2, Basic-helix-loop-helix-PAS protein MOP2, Hypoxia-inducible factor 2 alpha, HIF-2 alpha, HIF2 alpha, HIF-1 alpha-like factor, HLF

ARNT protein, Class E basic helix-loop-helix protein 2, bHLHe2, Dioxin receptor, nuclear translocator, Hypoxia-inducible factor 1 beta, HIF-1 beta

Crystal structure of the high affinity heterodimer of HIF2 C-terminal PAS domains in complex with the artificial ligand THS-044.

Crystal structure of the apo-high affinity HIF2 PAS-B heterodimer.

Crystal structure of the high affinity heterodimer of HIF2 C-terminal PAS domains with internally bound ethylene glycol.

Solution NMR structure of the HIF2alpha C-terminal PAS domain.

Solution NMR structure of the ARNT C-terminal PAS domain.

NMR-guided model of the heterodimer of wild-type HIF2alpha and ARNT C-terminal PAS domain.

Crystal structure of the ARNT C-terminal PAS domain.

Heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS020

Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017

to generate the biologically relevant complex, the symmetry operator (1/2-x,y-1/2,1-z) should applied to chain B.

The largest off-origin peak in the Patterson function is 8.90% of the height of the origin peak. No significant pseudotranslation is detected.

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures

20191225.v01 (using entries in the PDB archive December 25th 2019)