wwPDB validation report of PDB entry 3CV6

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

17-alpha-hydroxysteroid dehydrogenase, 17-alpha-HSD, 3-alpha-hydroxysteroid dehydrogenase, Dihydrodiol dehydrogenase type 1, DD1, Dihydrodiol dehydrogenase type 3, DD3

THERE ARE DIFFERENCES BETWEEN THE SEQRES AND THE SEQUENCE DATABASE. THIS IS A VARIANT AT THESE POSITIONS. THR221 IN MOLECULES A AND B MAKES CLOSE CONTACTS WITH THE COENZYME RESULTING IN A DEVIATION IN CHIRALITY.

The crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase GG225.226PP mutant in complex with inhibitor and cofactor NADP+.

The largest off-origin peak in the Patterson function is 3.85% of the height of the origin peak. No significant pseudotranslation is detected.

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures

20191225.v01 (using entries in the PDB archive December 25th 2019)