wwPDB validation report of PDB entry 2CJI

6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208707

CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031)COMPLEXED WITH FACTOR XA

COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG- CHLOROMETHYLKETONE

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55532

HUMAN COAGULATION FACTOR XA COMPLEXD WITH M55590

HUMAN COAGULATION FACTOR XA COMPLEXD WITH M55165

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55159

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55143

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55125

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55124

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M55113

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M54476

HUNMAN COAGULATION FACTOR XA COMPLEXD WITH M54471

HUMAN COAGULATION FACTOR XA COMPLEXD WITH M55192

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXEDWITH FXV673

FACTOR XA IN COMPLEX WITH (R)-2-(3- ADAMANTAN-1-YL-UREIDO)-3-(3-CARBAMIMIDOYL- PHENYL)-N-PHENETHYL-PROPIONAMIDE

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 79.

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 125.

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 41.

CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.

CRYSTAL STRUCTURE OF 3-CHLORO-N-[4-CHLORO -2-[[(4-CHLOROPHENYL)AMINO]CARBONYL]PHENYL]- 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-2- THIOPHENECARBOXAMIDE COMPLEXED WITHHUMAN FACTOR XA

CRYSTAL STRUCTURE OF 3-CHLORO-N-[4-CHLORO -2-[[(5-CHLORO-2-PYRIDINYL)AMINO]CARBONYL ]-6-METHOXYPHENYL]-4-[[(4,5-DIHYDRO-2- OXAZOLYL)METHYLAMINO]METHYL]-2- THIOPHENECARBOXAMIDE COMPLEXED WITH HUMAN FACTOR XA

HUMAN FACTOR XA COMPLEXED WITH 2-[3-(15N- AMINO-15N-IMINO-13C-METHYL)PHENOXY]-6-[3 -(15N-AMINO-13C-METHYL)PHENOXY]-3,5- DIFLUORO-4-METHYLPYRIDINE (ZK-806299), BINDING MODELFROM DOUBLE REDOR NMR AND MD SIMULATIONS.

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXEDWITH RPR132747

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXEDWITH RPR209685

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXEDWITH RPR208944

CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXEDWITH RPR200095

THEORETICAL MODEL OF THE TISSUE FACTOR/ FACTOR VIIA/FACTORXA COMPLEX

CRYSTAL STRUCTURE OF BLOOD COAGULATION FACTOR XA IN COMPLEXWITH ECOTIN M84R

FACTOR XA IN COMPLEX WITH THE INHIBITOR 1 -[6-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO(5, 4-C)PYRIDIN-2-YL] CARBONYL-2-CARBAMOYL-4 -(6-CHLORONAPHTH-2-YLSULPHONYL)PIPERAZINE

FACTOR XA IN COMPLEX WITH THE INHIBITOR 4 -[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2- METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN -2-YL]CARBONYL]PIPERAZINE

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S) -(3'-AMIDINO-3- BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID

CRYSTAL STRUCTURE OF FACTOR XA COMPLEXED TO RAZAXABAN

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 50

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 1

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 21

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH 43

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45

CRYSTAL STRUCTURE OF THE ANTITHROMBIN-S195A FACTOR XA-PENTASACCHARIDE COMPLEX

FACTOR XA IS A VITAMIN K-DEPENDENT GLYCOPROTEIN THAT CONVERTS PROTHROMBIN TO THROMBIN IN THE PRESENCE OF FACTOR VA, CALCIUM AND PHOSPHOLIPID DURING BLOOD CLOTTING
SOME RESIDUES IN CHAIN ARE NOT SEEN IN THE ELECTRON DENSITY. SEQUENCE DATABASE RESIDUES 1-45 (THE GLA DOMAIN) WERE BIOCHEMICALLY REMOVED IN CHAIN B

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

ACTIVATED FACTOR XA HEAVY CHAIN (E.C.3.4.21.6), FACTOR X LIGHT CHAIN (E.C.3.4.21.6)
Crystal structure of a Human Factor Xa inhibitor complex

The largest off-origin peak in the Patterson function is 6.63% of the height of the origin peak. No significant pseudotranslation is detected.

20191225.v01 (using entries in the PDB archive December 25th 2019)

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures