wwPDB validation report of PDB entry 5CGD

mGluR5 transmembrane domain from Homo Sapiens fused with T4-Lysozyme from Enterobacteria Phage T4 in complex with the new chemical entity (NCE): 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile
Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5

mGluR5,Lysis protein,Lysozyme,Muramidase,mGluR5

4OO9 contains the same protein complexed with mavoglurant

5CGC contains the same protein complexed with 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile

Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5 (E.C.3.2.1.17)
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)

The largest off-origin peak in the Patterson function is 7.45% of the height of the origin peak. No significant pseudotranslation is detected.

20191225.v01 (using entries in the PDB archive December 25th 2019)

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures