wwPDB validation report of PDB entry 2BVS

STRUCTURE OF THROMBIN INHIBITED BY AERUGINOSIN298-A FROM A BLUE-GREEN ALGA

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG2

THROMBIN COMPLEXED WITH HIRUGEN AND A BETA- STRAND MIMETIC INHIBITOR

CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE- CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR

ALPHA-THROMBIN COMPLEX WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

COMPLEX OF THROMBIN WITH AND INHIBITOR CONTAINING A NOVEL P1 MOIETY

HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D- PHE-PRO-AZALYS-ONP

HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO- AZALYS-ONP

MOL_ID: 1; MOLECULE: ALPHA-THROMBIN; CHAIN: L, H; EC: 3.4.21.5; MOL_ID: 2; MOLECULE: HIRUGEN; CHAIN: I; HETEROGEN: P- AMIDINO-PHENYL-PYRUVATE

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA- PRO-BOROMPG

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROVAL

NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT

THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225I MUTANT BOUND TO D- PHE-PRO-ARG- CHLOROMETHYLKETONE

THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES

THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND PROFLAVIN

X-RAY STRUCTURE OF THE COMPLEX OF HUMAN ALPHA THROMBIN WITH THE INHIBITOR SDZ 229- 357

HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R, R)]-4- [(AMINOIMINOMETHYL)AMINO]-N-[[1-[3- HYDROXY-2-[(2- NAPHTHALENYLSULFONYL)AMINO]-1- OXOPROPYL]-2-PYRROLIDINYL] METHYL]BUTANAMIDE (BMS-186282)

HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R, R)]-1- (AMINOIMINOMETHYL)-N-[[1-[N-[(2- NAPHTHALENYLSULFONYL)-L- SERYL]-PYRROLIDINYL] METHYL]-3-PIPERIDENECARBOXAMIDE (BMS- 189090)

STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1- BINDING, SUB- MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZOTHIOPHENE INHIBITOR 4

CRYSTAL STRUCTURE OF HUMAN APLHA-THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 3

CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 2

CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH BENZO[B]THIOPHENE INHIBITOR 1

CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5- AMIDINOINDOLE-4- BENZYLPIPERIDINE INHIBITOR

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON- ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON- ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

INTERACTION OF FACTOR XIII ACTIVATION PEPTIDE WITH ALPHA- THROMBIN: CRYSTAL STRUCTURE OF THE ENZYME-SUBSTRATE COMPLEX

COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN

SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN* RWJ-51438 COMPLEXAT 1.7 A

ALPHA-THROMBIN COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND BENZAMIDINE

ALPHA-THROMBIN COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND MD-805 (ARGATROBAN)

ALPHA-THROMBIN COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND NAPAP

ALPHA-THROMBIN COMPLEX WITH (DES-AMINO ASP 55) HIRUDIN (RESIDUES 55 - 65) AND D-PHE- PRO-ARG-CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

CRYSTAL STRUCTURE OF THE THROMBIN- THROMBOMODULIN COMPLEX

CRYSTAL STRUCTURE OF THE HUMAN ALPHA- THROMBIN-HAEMADIN COMPLEX: AN EXOSITE II- BINDING INHIBITOR

COMPLEX STRUCTURE OF HUMAN THROMBIN WITH N- METHYL-ARGININE INHIBITOR

DESIGN OF P1' AND P3' RESIDUES OF TRIVALENT THROMBIN INHIBITORS AND THEIR CRYSTAL STRUCTURES

ALPHA-THROMBIN TERNARY COMPLEX WITH EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR DANSYLARGININE N-(3-ETHYL -1,5-PENTANEDIYL) AMIDE (DAPA)

ALPHA-THROMBIN TERNARY COMPLEX WITH HIRUDIN AND FIBRINOPEPTIDE A

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITHBCH -10556 AND EXOSITE-DIRECTED PEPTIDE

A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI- CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE

SELECTIVITY AT S1, H2O DISPLACEMENT, UPA, TPA,SER190/ALA190 PROTEASE, STRUCTURE-BASED DRUG DESIGN

X-RAY STRUCTURE OF THE HUMAN ALPHA- THROMBIN COMPLEX WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.

X-RAY CRYSTAL STRUCTURE OF HUMAN ALPHA- THROMBIN WITH A TRIPEPTIDE PHOSPHONATE INHIBITOR.

PRETHROMBIN2 COMPLEXED WITH HIRUGEN (N- ACETYLHIRUDIN 53 - 64 WITH SULFATO-TYR 63)

ALPHA THROMBIN COMPLEXED WITH HIRUGEN (N- ACETYLHIRUDIN 53 - 64 WITH SULFATO-TYR 63)

ALPHA THROMBIN COMPLEXED WITH D-PHE-PRO- ARG- CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON NMR MODEL OF DEOXYRIBONUCLEIC ACID)

COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON X-RAY MODEL OF DEOXYRIBONUCLEIC ACID)

HUMAN ALPHA-THROMBIN COMPLEXED WITH A PEPTIDYL PYRIDINIUM METHYL KETONE CONTAINING BIVALENT INHIBITOR

ALPHA THROMBIN COMPLEXED WITH THROMBOMODULIN (NONDECAPEPTIDE) AND D-PHE-PRO-ARG- CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

ALPHA-THROMBIN COMPLEXED WITH DEOXYRIBONUCLEIC ACID (5'- D(GPGPTPTPGPGPTPGPTPGPGPTPTPGPG)-3') AND D-PHE-PRO-ARG- CHLOROMETHYLKETONE (PPACK ) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT

CRYSTAL STRUCTURE OF THE HEPARIN COFACTOR II -S195A THROMBINCOMPLEX

CRYSTAL STRUCTURE OF NATIVE S195A THROMBIN WITH ANUNOCCUPIED ACTIVE SITE

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVELBICYCLIC LACTAM INHIBITOR

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D) PHE-PRO-BOROARG- OH

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D) PHE-PRO-BOROLYS- OH

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D) PHE-PRO-BORO-N- BUTYL-AMIDINO-GLYCINE-OH

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D) PHE-PRO-BORO- HOMOLYS-OH

HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D) PHE-PRO- BOROORNITHINE-OH

CRYSTAL STRUCTURE OF THE ANTICOAGULANT SLOW FORM OF THROMBIN

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH L-378,622

THROMBIN IN COMPLEX WITH SELECTIVE MACROCYCLIC INHIBITOR AT1.8A

DESIGN OF WEAKLY BASIC THROMBIN INHIBITORS INCORPORATINGNOVEL P1 BINDING FUNCTIONS: MOLECULAR AND X- RAYCRYSTALLOGRAPHIC STUDIES.

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE NRS

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE NRP

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE NR'S

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE D-FPR'S

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE XA AND D-PHE-PRO- ARG CHLOROMETHYLKETONE (PPACK) WITH CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP

ALPHA-THROMBIN NON-COVALENTLY COMPLEXED WITH RECEPTOR BASED PEPTIDE NRP (CLEAVED, FIRST FOUR RESIDUES ONLY) AND HIRUGEN

THROMBIN IN COMPLEX WITH SELECTIVE MACROCYCLIC INHIBITOR

HUMAN ALPHA THROMBIN INHIBITED BY RPPGF AND HIRUGEN

HUMAN THROMBIN COMPLEXED WITH A D-PHE-PRO -ARG- TYPEINHIBITOR AND A C-TERMINAL HIRUDIN DERIVED EXO- SITEINHIBITOR

ELABORATE MANIFOLD OF SHORT HYDROGEN BOND ARRAYS MEDIATINGBINDING OF ACTIVE SITE- DIRECTED SERINE PROTEASE INHIBITORS

DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTSAT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190UPA)

CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB- ALPHA AND HUMAN ALPHA- THROMBIN

COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNEDFLUORINATED INHIBITOR

CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB- ALPHA AND ALPHA-THROMBIN AT 2.6A

CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE- MIMETIC INHIBITOR

NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS

HUMAN ALPHA-THROMBIN IN COMPLEX WITH BIVALENT, BENZAMIDINE- BASED SYNTHETIC INHIBITOR

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THROMBIN AND THECENTRAL "E" REGION OF FIBRIN

2.5A STRUCTURE OF ANTICOAGULANT THROMBIN VARIANT E217K

THROMBIN IN COMPLEX WITH NATURAL PRODUCT INHIBITOROSCILLARIN

NOVEL NON-COVALENT THROMBIN INHIBITORS INCORPORATING P1 4, 5,6,7- TETRAHYDROBENZOTHIAZOLE ARGININE SIDE CHAIN MIMETICS

FAST FORM OF THROMBIN MUTANT R(77A)A BOUND TO PPACK

CRYSTAL STRUCTURE OF THE PROCOAGULANT FAST FORM OF THROMBIN

CRYSTAL STRUCTUE OF THROMBIN IN COMPLEX WITH A POTENT P1HETEROCYCLE-ARYL BASED INHIBITOR

ANTITHROMBIN-ANHYDROTHROMBIN-HEPARIN TERNARY COMPLEXSTRUCTURE

CRYSTAL STRUCTURE ANALYSIS OF A NOVEL OXYGUANIDINE BOUND TOTHROMBIN

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH COMPOUND 1

CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH COMPOUND 14B

2.5A CRYSTAL STRUCTURE OF THE ANTITHROMBIN- THROMBIN- HEPARINTERNARY COMPLEX

HUMAN THROMBIN WITH ACTIVE SITE N-METHYL-D PHENYLALANYL-N- [5-(AMINOIMINOMETHYL)AMINO]- 1-{{BENZOTHIAZOLYL)CARBONYL] BUTYL]-L- PROLINAMIDE TRIFLUROACETATE AND EXOSITE-HIRUGEN

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D- PHE-PRO-ARG- CHLOROMETHYLKETONE

ALPHA-THROMBIN COMPLEX WITH HIRUGEN AND CYCLOTHEONAMIDE A

ALPHA-THROMBIN COMPLEXED WITH CGP 50,856 (D-PHE-PRO-ARG-PRO -GLY-GLY-GLY-GLY FOLLOWED BY RESIDUES 53 - 65 OF HIRUDIN, CLEAVED AFTER ARG I 3)

ALPHA-THROMBIN TERNARY COMPLEX WITH HIRUDIN (C-TERMINAL FRAGMENT, RESIDUES 55 - 65) AND PPACK (D-PHE-PRO-ARG- CHLOROMETHYLKETONE)

CRYSTAL STRUCTURE OF THE POTENT ANTICOAGULANT THROMBINMUTANT W215A/E217A IN FREE FORM

CRYSTAL STRUCTURE OF THE ANTICOAGULANT THROMBIN MUTANTW215A/E217A BOUND TO PPACK

CRYSTAL STRUCTURE OF THE THROMBIN MUTANT D221A/D222K

ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N- DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE

SPECIFITY FOR PLASMINOGEN ACTIVATOR INHIBITOR- 1

COMPLEX OF THROMBIN WITH DESIGNED INHIBITOR 7165

ALPHA-THROMBIN COMPLEX WITH SULFATED HIRUDIN (RESIDUES 54- 65) AND L-ARGININE TEMPLATE INHIBITOR CS107

CRYSTAL STRUCTURE OF THROMBIN BOUND TO HEPARIN

THROMBIN IN COMPLEX WITH AN AZAFLUORENYL INHIBITOR 23B

ALPHA-THROMBIN COMPLEX WITH HIRULOG I (CLEAVED BETWEEN ARG 3 AND PRO 4)

ALPHA-THROMBIN COMPLEX WITH D-PHE-PRO-ARG - CHLOROMETHYLKETONE (PPACK) CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP AND BOVINE PROTHROMBIN FRAGMENT 2

ALPHA-THROMBIN COMPLEX WITH D-PHE-PRO-ARG - CHLOROMETHYLKETONE (PPACK) CHLOROMETHYLKETONE REPLACED BY A METHYLENE GROUP AND HUMAN PROTHROMBIN FRAGMENT 2

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D- PHE-PRO-ARG- CHLOROMETHYLKETONE

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND FPAM (FIBRINOPEPTIDE A MIMIC)

ALPHA-THROMBIN COMPLEX WITH RECOMBINANT HIRUDIN (VARIANT 2, LYS 47)

THE CRYSTAL STRUCTURE OF ALPHA-THROMBIN- HIRUNORM IV COMPLEX REVEALS A NOVEL SPECIFICITY SITE RECOGNITION MODE.

HIRUNORMS ARE TRUE HIRUDIN MIMETICS. THE CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: HIRUNORM V COMPLEX

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2711.

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770.

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH FRAGMENT-BASED SMALL MOLECULES OCCUPYING THE S1 POCKET.

ALPHA THROMBIN (E.C.3.4.21.5), HIRUDIN VARIANT-2
Human thrombin complexed with fragment-based small molecules occupying the S1 pocket

BINDING SITE FOR CHAIN I OF HIRUDIN VARIANT-2

20191225.v01 (using entries in the PDB archive December 25th 2019)

geometric validation package for ligand chemistry in protein x-ray structures