wwPDB validation report of PDB entry 7BRE

Set1/Ash2 histone methyltransferase complex subunit ASH2
UNP residues 286-402 and UNP residues 445-504

Lysine N-methyltransferase 2B,Myeloid/lymphoid or mixed-lineage leukemia protein 4,Trithorax homolog 2,WW domain-binding protein 7,WBP-7

RBBP-5,Retinoblastoma-binding protein RBQ-3

Authors made a construct of ASH2L (Q9UBL3-3) that delete a loop deletion from 402-445, and the loop is replaced by a linker sequence (ISGRGS).

chain 'B' and (resid 2551 through 2581 )

chain 'B' and (resid 2582 through 2606 )

chain 'B' and (resid 2607 through 2624 )

chain 'B' and (resid 2625 through 2646 )

chain 'B' and (resid 2647 through 2715 )

chain 'E' and (resid 2551 through 2558 )

chain 'E' and (resid 2559 through 2568 )

chain 'E' and (resid 2569 through 2581 )

chain 'E' and (resid 2582 through 2591 )

chain 'E' and (resid 2592 through 2606 )

chain 'E' and (resid 2607 through 2624 )

chain 'E' and (resid 2625 through 2636 )

chain 'E' and (resid 2637 through 2646 )

chain 'E' and (resid 2647 through 2658 )

chain 'E' and (resid 2659 through 2686 )

chain 'E' and (resid 2687 through 2698 )

chain 'E' and (resid 2699 through 2715 )

The crystal structure of MLL2 in complex with ASH2L and RBBP5

The largest off-origin peak in the Patterson function is 7.42% of the height of the origin peak. No significant pseudotranslation is detected.

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures

20191225.v01 (using entries in the PDB archive December 25th 2019)