wwPDB validation report of PDB entry 1BBB

HEMOGLOBIN A (CARBONMONOXY) (ALPHA CHAIN)

HEMOGLOBIN A (CARBONMONOXY) (BETA CHAIN)

PREVIOUS CRYSTALLOGRAPHIC STUDIES HAVE SHOWN THAT WILD-TYPE HUMAN HEMOGLOBIN CAN ADOPT TWO STABLE QUATERNARY STRUCTURES, ONE FOR DEOXYHEMOGLOBIN (THE T STATE, E.G. PROTEIN DATA BANK ENTRIES 2HHB AND 1HHB) AND ONE FOR LIGANDED HEMOGLOBIN (THE R STATE, E.G. ENTRY 1HHO). THIS STRUCTURE OF HUMAN CARBONMONOXYHEMOGLOBIN REPRESENTS A SECOND QUATERNARY STRUCTURE (TERMED THE R2-STATE) FOR LIGANDED HUMAN HEMOGLOBIN. IT IS SIMILAR, BUT NOT IDENTICAL, TO THE LIGANDED STRUCTURE OF A NATURALLY OCCURRING MUTANT HEMOGLOBIN, HEMOGLOBIN YPSILANTI (ENTRY 1CMY).

A THIRD QUATERNARY STRUCTURE OF HUMAN HEMOGLOBIN A AT 1.7-ANGSTROMS RESOLUTION

The largest off-origin peak in the Patterson function is 4.13% of the height of the origin peak. No significant pseudotranslation is detected.

structure factor analysis and validation

geometric validation package for ligand chemistry in protein x-ray structures

20191225.v01 (using entries in the PDB archive December 25th 2019)