Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2

(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside

Structural basis for allosteric regulation of Human Topoisomerase II alpha.

Etoposide-bound Human Top2a DNA-binding/cleavage domain in state 2

DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3')

DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3')

French Infrastructure for Integrated Structural Biology (FRISBI)

Human Top2a DNA-binding/cleavage domain in State 2

Human Topoisomerase, Etoposide, DNA, ISOMERASE