The pointed end complex of dynactin bound to Hook3

Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.

Signal for dyneins, part of dynactin and part of Hook3 have been subtracted using signal subtraction

Medical Research Council (MRC, United Kingdom)

Overall structure of the dynactin complex

Map showing the signal subtraction and local refinement on dynactin's shoulder domain

Map showing parts of dynactin's shoulder domain at lower resolution

Map showing the signal subtraction and local refinement on dynactin's pointed end domain

Map showing the pointed end complex of dynactin bound to BICDR1

Map showing the pointed end complex of dynactin with the p150 projection docked

Model showing the pointed end complex of dynactin bound to BICD2

ARP1 actin related protein 1 homolog A, Actin, cytoplasmic 1, Arp11, Dynactin subunit 2, putative Hook3 coiled coil, Dynactin 6, Dynactin subunit 5, Hook3, Dynactin subunit 4
Dynactin, Complex, Scaffold, Cytoskeleton, STRUCTURAL PROTEIN