IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

4H-THIENO[3,2-B]PYROLE-5-CARBOXYLIC ACID

Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules.

DISORDERED REGIONS WERE MODELED STEREOCHEMICALLY. POOR DENSITY IS PRESENT FOR RESIDUES A57, A58, A59, A60, A61, A336, A337, A338, A339, A340, B59, B60, B61, B82, B83, B338, B339, B340. FINAL STRUCTURE HAS NO RESIDUES IN THE DISALLOWED REGION OF THE RAMACHANDRAN PLOT AS DEFINED IN THE CCP4 PROCHECK PROGRAM.

OXIDOREDUCTASE, FLAVOOXIDASE, NEUROTRANSMISSION