Anti-CRISPR protein AcrIF4 inhibits the type I-F CRISPR-Cas surveillance complex by blocking nuclease recruitment and DNA cleavage.

CRISPR type I-F/YPEST-associated protein Csy2

DNA (5'-D(P*AP*GP*CP*AP*GP*CP*TP*GP*CP*AP*CP*C)-3')

National Science Foundation (NSF, China)

Csy-AcrIF4-dsDNA-deltaCAS6F (focused/constituent map)