The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin

Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.

Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1

Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1

10% (v/v) 2-propanol, 100 mM Imidazole/ Hydrochloric acid, pH 8.0

National Natural Science Foundation of China (NSFC)

Ministry of Science and Technology (MoST, China)

Complex, Activator, Transcription, Drug Binding, Nuclear Receptor