X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

2-[4-(carbamimidamidomethyl)phenyl]ethanoic acid
2-[4-[(diaminomethylideneamino)methyl]phenyl]acetic acid

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.

Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE

CRYSTALLIZATION SOLUTION: 100MM MES, 200MM K/NAH2PO4, PH 5.5-6.0, 2 M NACL; RESERVOIR SOLUTION: 3-4M NACL

Protease, Inhibitor, Complex, Canavanine, HYDROLASE

binding site for residues 2UE A 611 and ON8 A 612

binding site for residues ON8 A 612 and TBG A 613

binding site for residues TBG A 613 and ON8 A 614

binding site for residues ON8 A 614 and 00S A 615