Fragment KCL_771 in complex with MAP kinase p38-alpha

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.

MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha

15% PEG400, 5% PEG550-MME, 0.1M CALCIUM ACETATE, 0.1M MES PH6.0

Medical Research Council (MRC, United Kingdom)

Mitogen-activated protein kinase 14 (E.C.2.7.11.24)

FBDD, FRAGMENT BASED DRUG DESIGN, P38, MAPK14, KINASE, TRANSFERASE