Crystal structure of IRAK4 kinase domain with inhibitor

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

Interleukin-1 receptor-associated kinase 4

IRAK-4,Renal carcinoma antigen NY-REN-64

0.03 M hexammine cobalt (III) chloride
0.2 M sodium acetate
0.05 w/v pluronic F-68
1.9 M sodium malonate pH 6.4

INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (E.C.2.7.11.1)