Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed with OXA-58, a Carbapenem hydrolyzing Class D betalactamase from Acinetobacter baumanii.

2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID

Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D beta-Lactamase of Acinetobacter baumannii.

0.1M Tris base/Hydrochloric acid (pH 8.0), 30% (w/v) PEG 3350

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

ACYL-ENZYME COMPLEX, OXA-58, 6Alpha-Hydroxymethylpenicillanate, HYDROLASE

binding site for Di-peptide ALP B 301 and SER B 83

binding site for Di-peptide ALP C 301 and SER C 83

binding site for Di-peptide ALP D 301 and SER D 83