Influenza C virus polymerase in complex with human ANP32A - Subclass 1

Host ANP32A mediates the assembly of the influenza virus replicase.

The structure has been determined by single particle cryo-EM. PDB ids 4XOS, 5D98, and 6RR7 were used as initial models after rigid body fitting in chimera.

Influenza C virus polymerase in complex with human ANP32A

Human Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)

Influenza viral RNA (vRNA) promoter 47mer

Single specimen tilt of 20 degrees for around three quarter of the images

RNA (5'-R(*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*GP*CP*CP*CP*UP*G)-3')

RNA-directed RNA polymerase catalytic subunit

Acidic leucine-rich nuclear phosphoprotein 32 family member A

Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1

Acidic nuclear phosphoprotein pp32,pp32,Leucine-rich acidic nuclear protein,LANP,Mapmodulin,Potent heat-stable protein phosphatase 2A inhibitor I1PP2A,Putative HLA-DR-associated protein I,PHAPI

Influenza C virus (strain C/Johannesburg/1/1966)

Medical Research Council (MRC, United Kingdom)

Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2,Signal peptide protein, YSIRK family, Acidic leucine-rich nuclear phosphoprotein 32 family member A/RNA Complex
Influenza Polymerase, ANP32, replication, RNA-dependent RNA polymerase, VIRAL PROTEIN