The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.

Tyrosine-protein phosphatase non-receptor type 11

Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3

0.2 M Sodium formate, 0.1 M Bicine pH 8.5, 15% w/v PEG 5000MME

The 100 Talents Program of Chinese Academy of Sciences

The Personalized Medicines-Molecular Signature-based Drug Discovery and Development Strategic Priority Research Program of the Chinese Academy of Sciences

Shanghai Municipal Committee of Science and Technology

A State High-Tech Development Plan (the 863 Program) Award

The National Key Research and Development Program

Sequence of the protein was based on Isoform 2 of database Q06124 (PTN11_HUMAN)

Tyrosine-protein phosphatase non-receptor type 11 (E.C.3.1.3.48)

phosphatase, SH2 domain, allosteric inhibitor, cancer, SIGNALING PROTEIN, HYDROLASE