Crystal Structure of phosphonate-modified recombinant A.17 antibody FAB fragment

8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE

Reactibodies Generated by Kinetic Selection Couple Chemical Reactivity with Favorable Protein Dynamics.

0.1M ADA BUFFER PH 6.5, 0.1M MGCL2, 20% PEG6000

CRYSTAL STRUCTURE OF RECOMBINANT A.17 ANTIBODY FAB FRAGMENT

8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE (XOP): THE LIGAND XOP IS COVALENTLY BOND TO TYR37 OF THE L CHAIN.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES REFINED INDIVIDUALLY

FAB A.17 HEAVY CHAIN, FAB A.17 LIGHT CHAIN