A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strains Jfh1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture Across Genotypes.

HCV-JFH1 NS5B POLYMERASE STRUCTURE AT 1.9 ANGSTROM

CRYSTAL STRUCTURE OF THE NS5B POLYMERASE FROM HEPATITIS C VIRUS (HCV) STRAIN JFH1

ENGINEERED RESIDUE IN CHAIN A, THR2827 TO ALA

RNA-DIRECTED RNA POLYMERASE (E.C.2.7.7.48)

TRANSFERASE, HEPACIVIRUS, NONSTRUCTURAL PROTEINS, REPLICATION, DE NOVO INITIATION, PRIMING