Structure of G9a in complex with compound 26a

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.

Histone-lysine N-methyltransferase EHMT2

Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a

0.1M Bis-Tris propane (pH7.5), 0.2M Sodium Fluoride, 10% Ethylene Glycol, 22% PEG3350

Japan Society for the Promotion of Science (JSPS)

chain 'A' and (resid 916 through 935 )

chain 'A' and (resid 936 through 954 )

chain 'A' and (resid 955 through 985 )

chain 'A' and (resid 986 through 1010 )

chain 'A' and (resid 1011 through 1030 )

chain 'A' and (resid 1031 through 1079 )

chain 'A' and (resid 1080 through 1106 )

chain 'A' and (resid 1107 through 1140 )

chain 'A' and (resid 1141 through 1155 )

chain 'A' and (resid 1156 through 1188 )

chain 'B' and (resid 917 through 935 )

chain 'B' and (resid 936 through 954 )

chain 'B' and (resid 955 through 970 )

chain 'B' and (resid 971 through 1030 )

chain 'B' and (resid 1031 through 1079 )

chain 'B' and (resid 1080 through 1106 )

chain 'B' and (resid 1107 through 1140 )

chain 'B' and (resid 1141 through 1155 )

chain 'B' and (resid 1156 through 1189 )

histone lysine methyltransferase, inhibitor, protein-inhibitor complex, TRANSFERASE