Crystal structure of the disulfide linked DH717.1 Fab dimer, derived from a macaque HIV-1 vaccine-induced Env glycan-reactive neutralizing antibody B cell lineage

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

DH717.1 heavy chain Fab fragment, DH717.1 light chain Fab fragment

Fab-dimerized, glycan-reactive, antibodies, HIV, IMMUNE SYSTEM

(chain 'C' and (resid 1 through 138 or resid 144 through 224))

(chain 'E' and (resid 1 through 138 or resid 144 through 224))

(chain 'H' and (resid 1 through 138 or resid 144 through 224))