crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix

Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.

Structural Basis for HIV-1 Neutralization by a Gp41 Fusion Intermediate-Directed Antibody.

SEQUENCE DERIVED FROM UNIPROT AC P04578 WHERE THREE REGIONS EACH EQUIVALENT TO AA 543-582 ARE INTERSPERSED BY TWO DIFFERENT REGIONS (EACH EQUIVALENT TO AA 625-662). LINKERS GGSGG AND GSSGG JOIN THE REGIONS AND ALTERNATE STARTING WITH GGSGG. A
5-HELIX INNER-CORE MIMETIC COMPRISED OF REPEATS OF RESIDUES 543-582 AND 625-662

HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN

HK20, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN

0.1 M HEPES PH 7.5, 0.2 M AMMONIUM SULPHATE, 25% PEG 3350 (W/V)

INTERACTIONS BETWEEN HIV-1 GP41 CORE AND DETERGENTS AND THEIR IMPLICATIONS FOR MEMBRANE FUSION

HELICAL INTERACTIONS IN THE HIV-1 GP41 CORE REVEALS STRUCTURAL BASIS FOR THE INHIBITORY ACTIVITY OF GP41 PEPTIDES

THEORETICAL MODEL OF CCR5 RECEPTOR IN COMPLEX WITH HIVGP120 ENVELOPE GLYCOPROTEIN AND CD4 RECEPTOR

HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY

CRYSTAL STRUCTURE ANALYSIS OF THE GP41 CORE MUTANT

HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4AND INDUCED NEUTRALIZING ANTIBODY 17B

CRYSTAL STRUCTURE ANALYSIS OF GP41 CORE MUTANT

CRYSTAL STRUCTURE OF THE HIV-1 NEUTRALIZING ANTIBODY D5 FAB BOUND TO THE GP41 INNER -CORE MIMETIC 5-HELIX

CRYSTAL STRUCTURE OF C14LINKMID/IQN17: A CROSS-LINKED INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 HYDROPHOBIC POCKET

SOLUTION ENSEMBLE STRUCTURES OF HIV-1 GP41 2F5 MAB EPITOPE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. DISORDERED LOOPS REGIONS OF GP41-5HB WERE NOT MODELED.

TRANSMEMBRANE PROTEIN GP41, HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN, HK20, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN

IMMUNE SYSTEM, ANTIBODY, MONOCLONAL CELLS, NEUTRALIZATION TESTS