HIV-1 reverse transcriptase Q151M:DNA binary complex

HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.

polydeoxyribonucleotide/polyribonucleotide hybrid

20 mM bis-Tris-HCl pH 6.0, 60 mM di-ammonium hydrogen citrate, 20 mM MgCl2, 1.5-3% PEG 6000, 2-4% sucrose, 4-8% glycerol

Japan Agency for Medical Research and Development (AMED)

oligosaccharide with reducing-end-to-reducing-end glycosidic bond

HIV-1, HBV, reverse transcriptase, drug resistance, drug sensitivity, TRANSFERASE-DNA complex