New substrate binding pockets for beta-secretase.

(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoic acid

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2

16% PEG8000, 100mM Cacodylate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 290K

beta secretase, memapsin2, BACE, ASP2, Aspartic protease, Alzheimer's disease, Drug design, HYDROLASE-HYDROLASE INHIBITOR complex