Crystal Structure of EncM (crystallized with 4 mM NADPH)

Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.

5 mg/mL EncM in 4 mM NADPH, 5 mM TES sodium, pH 7.7, 10% v/v glycerol, reservoir: 0.1 M HEPES sodium, pH 7.5, 0.2 M calcium acetate, 20% w/v PEG3350

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

The structure of EncM in complex with trifluorotriketide

The structure of EncM in complex with hydroxytetraketide

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT

Flavoenzyme, NADPH, vanillyl-alcohol oxidase/p-cresol methylhydroxylase fold, oxygenase, OXIDOREDUCTASE

binding site for Di-peptide FAD B 501 and HIS B 78
binding site for Di-peptide FAD D 501 and HIS D 78