OleP, the cytochrome P450 epoxidase from Streptomyces antibioticus involved in Oleandomycin biosynthesis: functional analysis and crystallographic structure in complex with clotrimazole.

Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis.

1.6 M Ammonium Sulphate, 0.1 M HEPES Sodium Salt pH 7.5, 2% (w/v) PEG 1000

Istituto Pasteur-Fondazione Cenci Bolognetti

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY

8.8a-oleandolide monooxygenase, OleP (E.C.1.14.14.1)

Monomer according to gel filtration chromatography

P450, clotrimazole, epoxidase, oleandomycin, OXIDOREDUCTASE