Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM)

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

DNA-directed RNA polymerase subunit alpha

DNA-directed RNA polymerase subunit beta

DNA-directed RNA polymerase subunit beta'

DNA-directed RNA polymerase subunit omega

RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha

RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta

RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'

RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

100 mM Tris-HCl, pH 8.4, 200 mM potassium chloride, 50 mM magnesium chloride, 9.5% PEG4000, VAPOR DIFFUSION, HANGING DROP, temperature 295K

Transcription, RNA polymerase, transcription inhibition, nucleoside-analog inhibitor, pseudouridimycin, TRANSFERASE-DNA complex