Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas

Molecular basis for regulation of Src by the docking protein p130Cas

Proto-oncogene tyrosine-protein kinase LCK

P56-LCK, LSK, T cell-specific protein-tyrosine kinase

p130cas, Breast cancer anti-estrogen resistance 1 protein

N-tris[hydroxymethyl]methyl-3-aminopropane-sulfonic acid, di_potasium hydrogen phosphate, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K

IN COMPLEX WITH THE PHOSPHOPEPTIDE TAIL OF LCK: TEGQ(PHOSPHO)YQPQPA

The peptide was chemically synthesized. Identical to naturally accured sequence in p130Cas

Proto-oncogene tyrosine-protein kinase LCK (E.C.2.7.1.112), CRK-associated substrate

Lck-Cas complex, LCK phospho-peptide complex, High affinity LCK-Cas complex, SIGNALING PROTEIN