Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K

The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

0.1M HEPES (pH 7.4), 0.1M MgCl2, 15% PEG3350, 10% isopropanol, 25% ethylene glycol

National Natural Science Foundation of China

National High Technology Research and Development Program of China

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

cAMP-specific 3',5'-cyclic phosphodiesterase 4D (E.C.3.1.4.53)

Natural PDE4 inhibtor, HYDROLASE-INHIBITOR complex