Crystal Structure of CahJ in Complex with Salicylic Acid and AMP

A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ.

100 mM Sodium Cacodylate pH 6.5, 1.7 M Sodium Acetate

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Ligase, Adenylation Domain, Peptide Synthetase