3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide

Structural study of ponatinib in inhibiting SRC kinase.

Proto-oncogene tyrosine-protein kinase Src

0.1M MES (pH 6.4), 50mM sodium acetate, 10mM MgCl2, 2% glycerol, 8% PEG 4000

National Natural Science Foundation of China (NSFC)

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(chain B and (resid 257 through 276 or (resid 277 and (name N or name CA or name C or name O or name CB )) or resid 278 through 407 or resid 424 through 468 or (resid 469 and (name N or name CA or name C or name O or name CB )) or resid 470 through 533 or resid 601))