Cryo-EM structure of PKD2 C331S disease variant

Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.

Residues ALA A 356 and PRO A 357 that are next to each other in the sample sequence are not properly linked: distance between C and N is 1.10

Residues ALA B 356 and PRO B 357 that are next to each other in the sample sequence are not properly linked: distance between C and N is 1.10

Residues ALA C 356 and PRO C 357 that are next to each other in the sample sequence are not properly linked: distance between C and N is 1.10

Residues ALA D 356 and PRO D 357 that are next to each other in the sample sequence are not properly linked: distance between C and N is 1.10

PC2,Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2

National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)