wildtype tryptophan synthase complexed with glycerol phosphate

On the Structural Basis of the Catalytic Mechanism and the Regulation of the Alpha Subunit of Tryptophan Synthase from Salmonella Typhimurium and Bx1 from Maize, Two Evolutionarily Related Enzymes.

10 MG/ML PROTEIN, RESERVOIR:50 MM TRIS-BIS-PROPANE PH 7.8, 100 MM NACL, 12% PEG8000, 50 MM GLYCEROL PHOSPHATE, 1.5 MM SPERMIDINE, 20 DEG, HANGING DROP IN THE DARK

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHAD60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA =2=BETA=2= COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE

TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF BETAA169L/BETAC170W DOUBLE MUTANT OFTRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUORO-INDOLE-PROPANOLPHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]ASPARTIC ACID

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]GLYCINE ACID

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]VALINE ACID

CRYSTAL STRUCTURE OF THE BETA-SER178PRO MUTANT OFTRYPTOPHAN SYNTHASE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM

CRYSTAL STRUCTURE OF THE TRYPTOPHAN SYNTHASE BETA-SER178PROMUTANT COMPLEXED WITH D,L- ALPHA-GLYCEROL-3-PHOSPHATE

CRYSTAL STRUCTURE OF THE TRYPTOPHAN SYNTHASE BETA-SER178PROMUTANT COMPLEXED WITH N-[1H- INDOL-3-YL-ACETYL]GLYCINE ACID

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH INDOLE GLYCEROLPHOSPHATE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH INDOLE PROPANOLPHOSPHATE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH L-SER BOUND TOTHE BETA SITE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH L-SERINE

CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM SALMONELLATYPHIMURIUM

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH INDOLE PROPANOL PHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH INDOLE GLYCEROL PHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH 1-[(2-HYDROXYLPHENYL) AMINO]3-GLYCEROLPHOSPHATE

TRYPTOPHAN SYNTHASE IN THE PRESENCE OF CESIUM, ROOM TEMPERATURE

TRYPTOPHAN SYNTHASE IN THE PRESENCE OF POTASSIUM AT ROOM TEMPERATURE

TRYPTOPHAN SYNTHASE WITH A MUTATION OF LYS 87 ->THR IN THE B SUBUNIT AND IN THE PRESENCE OF LIGAND L-SERINE

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZOYL)-2-AMINO-1- ETHYLPHOSPHATE (F6) - LOWF6 COMPLEX

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZOYL)-2-AMINO-1- ETHYLPHOSPHATE (F6) - HIGHF6 COMPLEX

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1- ETHYLPHOSPHATE (F9)

TRYPTOPHAN SYNTHASE IN COMPLEX WITH D- GLYCERALDEHYDE 3-PHOSPHATE (G3P)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1- ETHYLPHOSPHATE (F9)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH N-(4'-TRIFLUOROMETHOXYBENZOYL )-2-AMINO-1-ETHYLPHOSPHATE (F6)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH (NAPHTHALENE-2'-SULFONYL)-2 -AMINO-1-ETHYLPHOSPHATE (F19)

CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA=2 BETA=2= COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE

THE PROTEIN IS TETRAMER OF TWO ALPHA AND TWO BETA CHAINS.

PLP IS BOUND VIA A SCHIFF BASE BOND TO BETA LYS87

TRYPTOPHAN SYNTHASE ALPHA CHAIN (E.C.4.2.1.20), TRYPTOPHAN SYNTHASE BETA CHAIN (E.C.4.2.1.20)

LYASE, PYRIDOXAL PHOSPHATE, TRYPTOPHAN BIOSYNTHESIS