pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-((S)-2-acetamido-3,3-dimethylbutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 15)

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.

Transcription elongation factor B polypeptide 2

Transcription elongation factor B polypeptide 1

Von Hippel-Lindau disease tumor suppressor

Elongin 18 kDa subunit,Elongin-B,EloB,RNA polymerase II transcription factor SIII subunit B,SIII p18

Elongin 15 kDa subunit,Elongin-C,EloC,RNA polymerase II transcription factor SIII subunit C,SIII p15

Biotechnology and Biological Sciences Research Council

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED

Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1, Von Hippel-Lindau disease tumor suppressor

The biological unit is a trimer. There are four biological units in the asymmetric unit (chains A, B & C, chains D, E & F, chains G, H & I and chains J, K &L).

protein complex, ubiquitin ligase, hypoxia inducible factor, transcription, LIGASE