Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02)

Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.

MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome

Retinoblastoma-binding protein 5, WD repeat-containing protein 5, Histone-lysine N-methyltransferase 2A, Set1/Ash2 histone methyltransferase complex subunit ASH2

Histone H3.2, Histone H4, Histone H2A type 1, Histone H2B 1.1

Set1/Ash2 histone methyltransferase complex subunit ASH2

RBBP-5,Retinoblastoma-binding protein RBQ-3

Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX

KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1

National Institutes of Health/National Center for Research Resources (NIH/NCRR)

National Institutes of Health/National Cancer Institute (NIH/NCI)

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01)

MLL1-NCP, H3K4 methylation, TRANSFERASE, TRANSFERASE-STRUCTURAL PROTEIN-DNA complex