Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate

S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)

[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.

human diacylglycerol O-acyltransferase 1 complexed with oleoyl-CoA substrate
human diacylglycerol O-acyltransferase 1

ACAT-related gene product 1,Acyl-CoA retinol O-fatty-acyltransferase,Retinol O-fatty-acyltransferase,Diglyceride acyltransferase

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

Triglyceride Biosynthesis, Lipid Storage, Lipid Metabolism, TRANSFERASE