Post-catalytic complex of human Polymerase Mu (G433S) mutant with incoming dTTP

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Rosenbaum-Rock monochromator high-resolution double-crystal Si(220) sagittal focusing

DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3')

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

National Institutes of Health/National Cancer Institute (NIH/NCI)

THE AUTHORS STATE THAT THE ANOMALOUS SIGNAL IS OBSERVED AT ONE POSITION IN THIS STRUCTURE--AT THE METAL OCCUPYING THE METAL A SITE (PEAK > 6 SIGMA). NO KNOWN ANOMALOUS SCATTERERS WERE ADDED, SO THIS POSITION HAS BEEN PUTATIVELY MODELED AS SODIUM, WHICH IS CONSISTENT WITH ITS IDENTITY IN OTHER REPORTED STRUCTURES.

DNA-directed DNA/RNA polymerase mu/DNA Complex

Family X, nonhomologous end-joining, DNA double strand break repair, ribonucleotide incorporation, TRANSFERASE-DNA complex