Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Structural and functional characterization of a monoclonal antibody blocking TIGIT.

T-cell immunoreceptor with Ig and ITIM domains

V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3

200mM ammonium citrate, 20% (v/v) polyethylene glycol 3350

Antibody, Immune Checkpoint, TIGIT, IMMUNE SYSTEM

(chain "A" and (resid 25 through 35 or resid 37 through 43 or resid 45 through 62 or resid 65 through 81 or resid 83 through 128))

(chain "T" and (resid 25 through 35 or resid 37 through 43 or resid 45 through 62 or resid 65 through 81 or resid 83 through 128))

(chain "H" and (resid 2 through 12 or resid 14 through 42 or resid 44 through 82C or resid 84 through 112))

(chain "B" and (resid 2 through 12 or resid 14 through 42 or resid 44 through 86 or resid 88 through 120))