Crystal Structure of HIV-1 Reverse Transcriptase in Complex with N-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-N-methylacrylamide (JLJ684), a Non-nucleoside Inhibitor

Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography.

Human immunodeficiency virus type 1 group M subtype B (isolate BH10)

50 mM imidazole pH 6.8, 14% PEG 8,000, 100 mM ammonium sulfate, 15 mM magnesium sulfate, and 5 mM spermine

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)

RT is known to function as a heterodimer of p66 and p51 subunits

Reverse transcriptase/ribonuclease H (E.C.2.7.7.49, 2.7.7.7, 3.1.26.13), p51 RT

Polymerase, reverse transcriptase, non-nucleoside inhibitor, TRANSFERASE-HYDROLASE-INHIBITOR complex