Crystal structure of the cysteine depleted CYP3A4 bound to ritonavir

High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.

fragment 3-22 deletion; C58A; C64M; C98A, C239T; C377A; C468S; C-terminal 4-His tag

1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6-alpha-hydroxylase

National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)

MET ALA are the first two residues, the fragment 3-22 was deleted

cytochrome P450, CYP3A4, monooxygenase, cysteine mutation, ritonavir, OXIDOREDUCTASE-INHIBITOR complex