Crystal structure of DegS after backsoaking the activating peptide

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain

PEG 6000, MPD, magnesium chloride, HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 292K

Crystal structure of DegS in complex with activating peptide

stress response, protein quality control, PDZ, UPR, HtrA, hydrolase