Structure of Schistosoma mansoni Thioredoxin-Glutathione Reductase (SmTGR)

Glutathione Reductase and Thioredoxin Reductase at the Crossroad: The Structure of Schistosoma Mansoni Thioredoxin Glutathione Reductase

AFTER FIXING THE FIRST DOMAIN, THE SECOND DOMAIN WAS SEARCHED USING 1Z7R AS STARTING MODEL.

22% PEG 3350, 0.1M HEPES PH 7.2, 0.2M NANO3, 5MM DTT

SHEET
THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN
ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,
TWO SHEETS ARE DEFINED.

BELONGS TO THE CLASS-I PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE FAMILY.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. DENSITY FOR RESIDUES 1-7 AND 594-597 WAS NOT VISIBLE, THEREFORE THESE AMINO ACIDS WERE NOT MODELED.

THIOREDOXIN GLUTATHIONE REDUCTASE (E.C.1.6.4.5)

FAD, FLAVOPROTEIN, OXIDOREDUCTASE, CHIMERIC ENZYME, THIOL-MEDIATED DETOXIFICATION PATHWAY, REDOX-ACTIVE CENTER