Cryptococcus neoformans adenylosuccinate lyase

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Escherichia coli 'BL21-Gold(DE3)pLysS AG'

0.1 M Bis-Tris/citric acid pH 6.5, 17% PEG 3350 and 0.12 M sodium chloride

National Health and Medical Research Council (NHMRC, Australia)

multiangle light scattering supports tetramer assembly

lyase, fumerase, adenylosuccinate, SAICAR