Fibroblast growth factor receptor 1 kinase in complex with JK-P3

Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, B FGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE

20% PEG8000, 20% ETHYLENE GLYCOL, 0.2M AMMONIUM SULPHATE, 0.1M PCTP PH 6.75

FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE IN COMPLEX WITH JK-P5

TWO MUTATIONS INTRODUCED TO IMPROVE CRYSTALLISATION AND REDUCE AGGREGATION C488A C584S

DISORDERED SIDE-CHAINS WERE TRUNCATED TO THE LAST VISIBLE ATOM.

FIBROBLAST GROWTH FACTOR RECEPTOR 1 (E.C.2.7.10.1)

TRANSFERASE, RECEPTOR TYROSINE KINASE, TRANSFERASE INHIBITOR