Fibroblast growth factor receptor 1 kinase in complex with JK-P5

Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, BFGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE

20% PEG8000, 20% ETHLYENE GLYCOL, 0.2M AMMONIUM SULPHATE, 0.1M PCTP PH 6.75

FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE IN COMPLEX WITH JK-P3

TWO MUTATIONS TO IMPROVE CRYSTALLISATION AND REDUCE AGGREGATION C488A AND C584S

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED. HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT. DISORDERED SIDE-CHAINS WERE TRUNCATED TO THE LAST VISIBLE ATOM

FIBROBLAST GROWTH FACTOR RECEPTOR 1 (E.C.2.7.10.1)